Recently, Oravax Medical Inc., ("Oravax" has entered into a licensing agreement with Premas Biotech to make available for commercialization of Oravax's virus-like particle (VLP) vaccine technology. Oravax is a joint venture between Oramed Pharmaceuticals Inc., a US-based company (the majority shareholder), and Gurugram, India-based life sciences company, Premas Biotech ("Premas"). While the terms of the license agreement have not been disclosed, Oravax will be entitled to royalties upon commercialization of this vaccine in India.
Premas Biotech has developed a triple antigen Covid-19 vaccine candidate that targets three SARS CoV-2 virus surface proteins. The vaccine candidate has been developed by Premas' proprietary difficult-to-express proteins platform, D-CryptTM, which is believed to target proteins less susceptible to mutation, thus making the vaccine potentially more effective over other existing technologies against various variants of the COVID-19 virus. Premas have cloned, expressed, and purified all the variants of spike protein along with the N, M, and E proteins, that form an array of very high-quality antigens for diagnostics development. Oravax on the other hand combines technology acquired from its parents: Premas Biotech and protein oral delivery (PODT) oral delivery technology of Oramed Pharmaceuticals.
Under this agreement, Oravax has out-licensed certain rights in the territory of India to Premas Biotech. The VLP platform technology can be delivered either via injection or orally, and under this license agreement, Oravax has licensed to Premas the right to develop an injectable version of its VLP technology with an aim to address the urgent need for a vaccine that is effective against the Delta variant. Premas plans to manufacture, test, and potentially commercialize the injectable version of the VLP vaccine in India.
The VLP vaccine is being tested in preclinical studies against COVID-19 variants including the Delta variant. The VLP vaccine technology is highly scalable with a low cost of goods and easily transferable. The oral VLP COVID-19 vaccine is being developed for use both as a standalone vaccine as well as a booster for people who have been previously vaccinated for COVID-19.
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