UK: Harnessing Artificial Intelligence For Data Analytics In Digital Health

Last Updated: 2 September 2019
Article by Nadia Gracias

There's an abundance of data being captured and analysed as a result of artificial intelligence (AI) being used in digital health. By 2025, market research indicates that global big data in healthcare analysis forecast will reach $68.75B by 2020.

Healthcare data capture is growing at a fast pace and is expected to surpass 2,314 exabytes by 2020. This growth is stimulated by declining storage costs and the emergence of organisational reliability on cloud-based services and subscription models.

European Union is set to invest $24B into artificial intelligence (AI) by 2020 and healthcare is one of the market sectors that stands to benefit the most as it has become so reliant on big data.

Big data in healthcare market will be driven by an urgent need to control rising healthcare costs and to improve patient outcomes and resource management. Analytics services contributed the lion’s share of $5.80B in 2017 alone.

The spotlight is very much on the UK. Heavyweights like Google's DeepMind Health*, are using AI to mine medical records and processing hundreds of thousands of medical data profiles in minutes at Moorfields Eye Hospital and University College London Hospitals (UCLH) Trust.

BioBeats* is a UK digital health and AI company that creates easy-to-use corporate and personal wellness solutions to combat stress. Alongside their funding from Oxford Sciences Innovation, White Cloud Capital and IQ Capital, the digital health start-up received backing from actor and singer, Will Smith in August 2018, bringing* the total funding for BioBeats to $6M.

Cambridge, UK has grown to be a petri-dish for innovation, globally renowned for incubating biotech and digital health innovation — spin-outs and scale-ups in life sciences, digital therapeutics and biotech. Cambridge (known as Silicon Fen) has a higher than average digital density compared to most UK cities and is the third largest bio-cluster in the world (following Silicon Valley and Boston area) with £681 million [$868 million] in venture capital in 2017.

Trailblazers such as Cambridge Antibody Technology (acquired by Astra Zeneca in 2006 for £702m.), Kymab (currently preparing for a NASDAQ IPO), and Solexa, have been the UK’s biggest biotech success stories, firmly paving the yellow brick road all the way to Cambridge for the next aspiring biotech unicorn.

AI digital start-ups like Benevolent AI and Healx* are using AI to speed up the process of drug development, discovering and developing treatments for rare diseases by combining AI with pharmacological expertise and patient engagement.

Benevolent AI, a UK tech unicorn valued at more than £1B, opened up a facility in Cambridge in 2018 after they acquired a lab at the Babraham Research Campus. . And, Healx has raised $11.9 M, including a $10M Series A round led by Balderton Capital.

But with this exponential growth in data harvesting, what are the biggest risks to digital health companies and start-ups with all this influx of this data and upsurge in health data analytics as a result of AI?

In one word. Data

Without placing a dampener on this exciting growth story, in the words of the UK Information Commissioner’s Office (‘ICO’), while finding that the Royal Free London NHS Trust Hospital and Google’s DeepMind failed to comply with the privacy laws in 2017, “[..] the price of innovation does not need to be the erosion of fundamental privacy rights”.

In this case, DeepMind had developed an app (‘Streams’) pooling together health data of 1.6 million patients from various sources, obtained from the Royal Free London NHS Hospital, to help clinicians monitor the onset of serious conditions such as acute kidney injury, sepsis or acute liver failure. Although in response to the ICO’s criticism numerous changes were implemented, in 2018 DeepMind was fully merged with Google to make Streams available globally which resulted in many of the changes being scrapped.

And, here's a little known fact: despite DeepMind’s pioneering work in AI, at its inception Streams itself did not use any AI. Since the merger, AI was finally woven into Streams, leading to the exciting announcement last month of the development of an AI model that can accurately predict the onset of acute kidney injury up to 48 hours in advance.

In health data analysis, it's not the technology that's key, it's the access to a broad enough data set that is vital. The most valuable asset to an AI health-tech venture is not the AI platform, but the data. Without a broad clinically representative data set to learn on the AI will not provide a clinically usable output.

When such outputs may be relied on to make critical life saving decisions, the quality of the data on which the AI learns to make its predictions is crucial — i.e. how clinically representative the input data is, of the patient population that is intended to be treated based on the AI’s output. For example, DeepMind's Streams AI was trained on patient data from the US Department for Veteran Affairs ('US DVA'). As the dataset from US DVA belonged to an overwhelmingly male (93.6%) group, it was not representative of the general patient population which has a more balanced gender demographic. This is reflected in Streams' performance across gender (and separately ethnicity), where the AI model's performance is lower for women.

Since the ICO's remarks in 2017, the number of data breaches in the digital health sector has only grown exponentially year on year, including exposure of sensitive medical data.

Therefore, when data collection or analysis is central to the technology being built, the privacy of users should be one of the key values driving such innovation. Strong risk management should motivate innovators to factor privacy into product development right from day minus, not as an afterthought.

Why? Privacy barriers and future privacy opt-outs need to be carefully built in to limit data collection by the system to ensure the technology is compliant by its very design. Attempts to retrofit prototypes or products right before roll out to comply with privacy laws usually don’t end well.

A good starting point is to establish the legal basis under privacy laws for data collection. Carrying out privacy impact assessments to understand what further measures need to be taken not only to comply with such laws, but also to build user trust through greater transparency. Planning regular data audits to ensure the original model is still suitable for any new applications.

As a final word, it is also worth remembering that the life sciences and health care industries are already some of the most heavily regulated sectors. Some health products and services are often simultaneously regulated by a range of regulations and regulators in the UK, such as the MHRA (Medicines and Healthcare products Regulatory Authority), the CQC (Care Quality Commission), the Human Tissue Authority and if applicable even by professional licensing bodies such as the General Medical Council. Such companies, their senior management and their products will already need to be compliant with many of the standards relating to informed consent, confidentiality and patient privacy right from product or service launch and throughout the product life cycle.

In the next part of this series in September , we will focus on gene therapy which is predicted to be one of the next biggest trends in biotech. AI is set to revolutionise gene therapy making precision editing and highly personalised healthcare a reality. Alongside gene therapy's unique history with Cambridge and why Cambridge may continue to hold the key to its future success, we will look at several key intellectual property (IP) issues this raises, including around AI as an inventor. Stay tuned!

The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.

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